The effects of corticosteroids and nonsteroidal anti-inflammatory drugs, including aspirin, on coagulation

  • Eric Hodgson Nelson Mandela Medical University
Keywords: coagulation, corticosteroids, nonsteroidal anti-inflammatory drugs, NSAIDs


The immune and coagulation systems have numerous interactions, as evidenced by the increased risk of venous thromboembolism in inflammatory bowel disease. In general, proinflammatory states are prothrombotic, while a reduction in inflammation reduces thrombotic risk. Corticosteroids, such as hydrocortisone and prednisone, tend to reduce inflammation and thus thrombosis, while being prothrombotic in non-inflammatory states, e.g. Cushing’s syndrome. The nonsteroidal anti-inflammatory drugs also have a dual effect, through interaction with different cyclo-oxygenase enzyme isoforms, on platelets and the vascular endothelium.

Author Biography

Eric Hodgson, Nelson Mandela Medical University
FCA (SA)(Crit Care) Clinical Department Manager - Anaesthesia; and Pain Clinician Inkosi Albert Luthuli Central Hospital; and Clinical Associate Department of Anaesthesia and Critical Care Nelson R Mandela School of Medicine
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