Review Articles

Gastro-oesophageal reflux: An overview of the cost-effectiveness of pharmacotherapeutic treatment options

Gustav Schellack, J. C. Meyer, Natalie Schellack
South African Family Practice | Vol 58, No 2 : March/April| a4468 | DOI: https://doi.org/10.4102/safp.v58i2.4468 | ©
Submitted: 21 April 2016 | Published: 01 March 2016

About the author(s)

Gustav Schellack, Department of Pharmacy, Faculty of Health Sciences, Sefako Makgatho Health Sciences University (SMU), South Africa
J. C. Meyer, Department of Pharmacy, Faculty of Health Sciences, Sefako Makgatho Health Sciences University (SMU), South Africa
Natalie Schellack, Department of Pharmacy, Faculty of Health Sciences, Sefako Makgatho Health Sciences University (SMU), South Africa

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Abstract

Gastro-oesophageal reflux disease (GORD) produces symptoms that cause great irritation to the patient. Pharmacotherapeutic management is directed at minimising these symptoms and reducing the causative factors, e.g. acid production, thereby providing relieve. Currently available agents include simple antacids and acid suppression therapy, including histamine 2-receptor antagonists, proton pump inhibitors, mucosal or cytoprotective agents, pro-motility agents. Deciding on appropriate therapy will be dependent on the diagnosis, side-effects and cost-effectiveness of the treatment.

Keywords

GORD; gastro-oesophageal reflux; PPIs; proton-pump inhibitors; cost-effectiveness

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