Review Articles

Evidence that changes the way you practice Bipolar Disorder: Mania and depression explained

K. Outhoff
South African Family Practice | Vol 58, No 3 : May/June| a4505 | DOI: | © 2016 K. Outhoff | This work is licensed under CC Attribution 4.0
Submitted: 08 June 2016 | Published: 01 May 2016

About the author(s)

K. Outhoff, Department of Pharmacology, Faculty of Health Sciences, University of Pretoria, Pretoria, South Africa

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Bipolar Disorder (BD) is characterised by alternating discrete episodes of depression and mania.1 Rational pharmacotherapy necessitates an appreciation of these different phases and of the possible underlying pathophysiology. A greater understanding of the pathogenesis of BD has boosted awareness of how anti-bipolar drugs work, and vice versa.2 This bidirectional relationship has amplified knowledge in both disciplines.


bipolar disorder; mania; depression


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