Original Research

Performance of free prostate-specific antigen ratio in differentiating between prostatic cancer and benign prostatic lesions at a referral hospital in South Africa

Boitumelo Phiri-Ramongane, Ayeaye Khine
South African Family Practice | Vol 60, No 4 : July/August| a4889 | DOI: https://doi.org/10.4102/safp.v60i4.4889 | © 2019 Boitumelo Phiri-Ramongane, Ayeaye Khine | This work is licensed under CC Attribution 4.0
Submitted: 25 October 2019 | Published: 28 August 2018

About the author(s)

Boitumelo Phiri-Ramongane, Sefako Makgatho Health Science University; National Health Laboratory Services; Dr George Mukhari Academic Hospital, Medunsa, South Africa
Ayeaye Khine, Sefako Makgatho Health Science University; National Health Laboratory Services; Dr George Mukhari Academic Hospital, Medunsa, South Africa

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Abstract

Background: Prostate cancer is a leading cause of morbidity and mortality in our male population, thus screening initiatives will help to improve outcomes. The current screening marker, total prostate-specific antigen (PSA), is not prostate cancer specific. The development of percentage free PSA (%FPSA) has largely improved the detection of prostate cancer.
Objectives: To assess the performance of %FPSA ratio at the 25% cut-off and its ability to distinguish between prostate cancer and benign prostatic lesions.
Methods: This was a retrospective study conducted on male patients with total prostate-specific antigen values < 10 ng/ml and with prostate histology results. Male patients with total prostate-specific antigen between 4 and 10 ng/ml had their free prostate-specific antigen determined together with the calculation of the free prostate-specific antigen ratio. The ratio was then correlated with prostate histology results to determine the presence of prostate cancer at the cut-off ratio of 25%.
Results: Prostate cancer was detected in 28 (21.37%) patients out of the total population of 131. Ninety-two patients had a FPSA ratio of < 25%, 22 (22.8%) of whom were found to have prostate cancer. Notably the sensitivity and specificity were found to be 86% and 27% respectively, with a positive predictive of value of 21% at this cut-off.
Conclusions: The study demonstrates a %FPSA ratio of 25% not to be a good discriminator between prostatic cancerous and benign lesions. It is thus recommended that a prostate biopsy should be done based on clinical examination findings rather than the level of total prostate specific antigen from 0–10 ng/ml or %FPSA ratio.


Keywords

diagnostic accuracy; non-communicable diseases; prostatic neoplasm; screening

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