Review Articles

Mind your state: Insights into antidepressant nonadherence

De Wet Wolmarans, Sarel J. Brand
South African Family Practice | Vol 58, No 4 : July/August| a4509 | DOI: https://doi.org/10.4102/safp.v58i4.4509 | © 2016 De Wet Wolmarans | This work is licensed under CC Attribution 4.0
Submitted: 13 June 2016 | Published: 04 August 2016

About the author(s)

De Wet Wolmarans, Centre of Excellence for Pharmaceutical Sciences, Division of Pharmacology, Faculty of Health Sciences, North-West University, South Africa
Sarel J. Brand, Centre of Excellence for Pharmaceutical Sciences, Division of Pharmacology, Faculty of Health Sciences, North-West University, South Africa

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Abstract

Major depressive disorder (MDD) is an insidious disease and affects up to 15% of the global population. Although MDD responds to a wide range of pharmacological treatment options, a number of factors, i.e. not adhering to treatment for at least 4–12 months, contribute to antidepressants not being highly effective. In an attempt to aid clinicians in improving the adherence rates among MDD patients, the current paper will divulge in more detail the possible explanations of why individuals with MDD find it difficult to adhere to prescribed regimens.

Keywords

major depressive disorder; antidepressants; non-adherence

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